Stimulating the Brain’s Memory Circuits —
Investigating A New Approach to Alzheimer’s
Functional Neuromodulation Ltd. is investigating the use of deep brain stimulation of the fornix (DBS-f) to drive neural activity and modulate the brain’s memory circuit. Building on early clinical data, Functional Neuromodulation has commitments of $13.4 million and has partnered with Medtronic, the pioneer of DBS technology. The company expects to begin a Phase II multi-center clinical trial of DBS-f in patients with mild probable Alzheimer’s in 2012. LEARN MORE
NEWS
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MAY 9, 2012 Study Demonstrates that Deep Brain Stimulation May Hold Promise for Mild Alzheimer’s DiseaseA pilot study published this week in the Archives of Neurology suggests that mild electrical stimulation of target memory regions of the brain appears to increase neuronal activity. One year of deep brain stimulation increased brain metabolism and was associated with better outcomes in cognition, memory and quality of life. |
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OUR APPROACHDeep brain stimulation (DBS) uses a surgically implanted medical device, similar to a cardiac pacemaker, to deliver mild electrical pulses to precisely targeted areas of the brain. Functional Neuromodulation is advancing DBS of the fornix in the treatment of Alzheimer’s. The fornix is a major inflow and output pathway in the brain’s memory circuit that has been shown to be one of the first areas of the brain affected by Alzheimer’s. |
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ABOUT ALZHEIMER'S DISEASEAlzheimer’s is a progressively debilitating disease that slowly destroys memory and thinking skills, ultimately resulting in death. Alzheimer’s is the most common cause of dementia among older persons, affecting 13% over age 64 and nearly 50% over 85. Learn More |
Functional Neuromodulation, Ltd. | 200 Front Street West | Suite 3004 | P.O. Box 31 | Toronto, Ontario M5V 3K2 | (866) 296-4040 | info@fxneuromod.com
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